{"id":466,"date":"2026-06-12T10:30:00","date_gmt":"2026-06-12T08:30:00","guid":{"rendered":"https:\/\/dr-singer.net\/blog\/?p=466"},"modified":"2026-06-05T15:40:36","modified_gmt":"2026-06-05T13:40:36","slug":"stoert-schwarzer-kaffee-die-entgiftungsphase-ii-der-leber-bei-gesunden-menschen","status":"publish","type":"post","link":"https:\/\/dr-singer.net\/blog\/2026\/06\/12\/stoert-schwarzer-kaffee-die-entgiftungsphase-ii-der-leber-bei-gesunden-menschen\/","title":{"rendered":"St\u00f6rt schwarzer Kaffee die Entgiftungsphase II der Leber bei gesunden Menschen?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Zahlreiche Studien zeigen, dass Kaffee lebersch\u00fctzende Effekte hat, wenn der K\u00f6rper insgesamt gut versorgt ist.<br><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Genetisch bedingte langsame Koffeinverstoffwechselung (CYP1A2-Polymorphismus), sehr hohe Koffeinmengen, intensive Stresssituationen, die zu einer hohen Cortisolbelastung und so zu einer Systembelastung f\u00fchren, k\u00f6nnen die Entgiftungsprozesse der Leber beeinflussen.<br><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Entscheidend f\u00fcr die Phase II Entgiftung der Leber sind vor allem der N\u00e4hrstoffstatus (Glycin, Cystein, B-Vitamine etc.) und die allgemeine Lebergesundheit.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Glycin ist eine Aminos\u00e4ure, die f\u00fcr die Entgiftung wichtige Funktionen in der Leber erf\u00fcllt. Es unterst\u00fctzt die Bindung und Ausscheidung von Schadstoffen und ist ein wesentlicher Bestandteil von Glutathion \u2013 dem wichtigsten k\u00f6rpereigenen antioxidativen Schutzsystem.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Niedrige Glycinspiegel sind mit Fettlebererkrankungen, oxidativem Stress und einer verminderten Glutathionbildung assoziiert.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"468\" src=\"https:\/\/dr-singer.net\/blog\/wp-content\/uploads\/2026\/06\/12_6Ment-819x1024.jpg\" alt=\"\" class=\"wp-image-468\"\/><\/figure>\n<\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Literatur:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0278691507004486?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0278691507004486?via%3Dihub<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3155927\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3155927<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7982985\/?\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7982985\/?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35975308\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35975308<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/202502\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/202502<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4242593\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4242593<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Genetics of caffeine consumption and responses to caffeine<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.fitnessgenes.com\/blog\/caffeine-metabolism-and-heart-health?\">https:\/\/www.fitnessgenes.com\/blog\/caffeine-metabolism-and-heart-health?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Trait: Caffeine metabolism and heart health<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002916522031355?\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002916522031355?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-46931-0?\">https:\/\/www.nature.com\/articles\/s41598-019-46931-0?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine\u2019s Effect on Postprandial Glycaemia<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/diabetesjournals.org\/care\/article\/37\/2\/569\/29536\/Caffeinated-and-Decaffeinated-Coffee-Consumption?\">https:\/\/diabetesjournals.org\/care\/article\/37\/2\/569\/29536\/Caffeinated-and-Decaffeinated-Coffee-Consumption?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5549431\/?\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5549431\/?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7982985\/?\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7982985\/?<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Sie finden uns unter fb.me\/praxis.dr.p.singer, ig.me\/dr.p.singer, <a href=\"http:\/\/facebook.com\/groups\/regenerativemedizin\">http:\/\/facebook.com\/groups\/regenerativemedizin<\/a>, <a href=\"https:\/\/www.dr-singer.net\/blog\">https:\/\/www.dr-singer.net\/blog<\/a> und praxis.dr-singer.net<\/em><br><\/p>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\"><br>Design KI-unterst\u00fctzt<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zahlreiche Studien zeigen, dass Kaffee lebersch\u00fctzende Effekte hat, wenn der K\u00f6rper insgesamt gut versorgt ist. Genetisch bedingte langsame Koffeinverstoffwechselung (CYP1A2-Polymorphismus), sehr hohe Koffeinmengen, intensive Stresssituationen, die zu einer hohen Cortisolbelastung&#8230;<\/p>\n","protected":false},"author":1,"featured_media":468,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[3,169,892,887,886,5,891,121,885,889,890,888,128,165,373,378,10,4,2],"class_list":["post-466","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medizin","tag-behandlungsmethoden","tag-coffee","tag-cystein","tag-detox","tag-detoxification","tag-drpsinger","tag-entgiftung","tag-gesundheit","tag-glutathion","tag-glutathione","tag-glycin","tag-glycine-cysteine","tag-health","tag-kaffee","tag-leber","tag-liver","tag-medicine","tag-medizin","tag-treatmentmethods","entry"],"_links":{"self":[{"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/posts\/466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/comments?post=466"}],"version-history":[{"count":1,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/posts\/466\/revisions"}],"predecessor-version":[{"id":469,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/posts\/466\/revisions\/469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/media\/468"}],"wp:attachment":[{"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/media?parent=466"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/categories?post=466"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-singer.net\/blog\/wp-json\/wp\/v2\/tags?post=466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}